Dynamics of Living Matter

Biomimetics of structural colours: materials, methods and applications

AG Dumanli & T Savin ✉ | in Bioinspired Inorganic Materials: Structure and Function, Chapter 4 (2019)

Fingering instabilities in tissue invasion: an active fluid model

MJ Bogdan & T Savin ✉ | Royal Society Open Science 5:181579 (2018)

Solution fibre spinning technique for the fabrication of tuneable decellularised matrix-laden fibres and fibrous micromembranes

Z Li, J Tuffin, IM Lei, FS Ruggeri, NS Lewis, EL Gill, T Savin, L Huleihel, SF Badylak, T Knowles, SC Satchell, GI Welsh, MA Saleem & YYS Huang ✉ | Acta Biomaterialia 78:111 (2018)

Errors in energy landscapes measured with particle tracking

MJ Bogdan & T Savin ✉ | Biophysical Journal 115:139 (2018)

A physical approach to model occlusions in the retinal microvasculature

O Fleck & T Savin ✉ | Eye 32:189 (2018)

Recent advances in the biomimicry of structural colours

AG Dumanli & T Savin ✉ | Chemical Society Reviews 45:6698 (2016)

Research trends in biological fluid dynamics

S Jung ✉, AE Staples ✉, JO Dabiri, AL Marsden, M Prakash, KA Davis, SC Shadden, T Savin, L Bourouiba & J Sznitman | USNC/TAM Rep. (2016)

Nonequilibrium thermodynamics of an interface

M Schweizer, HC Öttinger ✉ & T Savin ✉ | Physical Review E 93:052803 (2016)

Pressure-driven occlusive flow of a confined red blood cell

T Savin, MM Bandi & L Mahadevan ✉ | Soft Matter 12:562 (2016)

Thermodynamic formulation of flowing soft matter with transient forces

T Savin ✉, WJ Briels & HC Öttinger | Rheologica Acta 52:23 (2013)

Fibers with integrated mechanochemical switches: minimalistic design principles derived from fibronectin

O Peleg, T Savin, GV Kolmakov, IG Salib, AC Balazs, M Kröger ✉ & V Vogel ✉ | Biophysical Journal 103:1909 (2012)

International Workshop on Nonequilibrium Thermodynamics (IWNET 2012) and 3rd Lars Onsager Symposium

D Taj & T Savin ✉ | Applied Rheology 22:274 (2012)

A method for tensile tests of biological tissues at the mesoscale

T Savin, AE Shyer & L Mahadevan ✉ | Journal of Applied Physics 111:074704 (2012)

Local equilibrium of the Gibbs interface in two-phase systems

T Savin ✉, KS Glavatskiy, S Kjelstrup, HC Öttinger & D Bedeaux | Europhysics Letters 97:40002 (2012)

La morphogenèse de l'enroulement intestinal | Gut looping morphogenesis

T Savin ✉ | médecine/sciences 27:1061 (2011)

Using mesoscopic models to design strong and tough biomimetic polymer networks

IG Salib, GV Kolmakov, BJ Bucior, O Peleg, M Kröger, T Savin, V Vogel, K Matyjaszewski & AC Balazs ✉ | Langmuir 27:13796 (2011)

On the growth and form of the gut

T Savin =, NA Kurpios =, AE Shyer =, P Florescu, H Liang, L Mahadevan ✉ & CJ Tabin | Nature 476:57 (2011)

A rational approach to noise discrimination in video microscopy particle tracking

T Savin, PT Spicer & PS Doyle ✉ | Applied Physics Letters 93:024102 (2008)

Statistical and sampling issues when using multiple particle tracking

T Savin & PS Doyle ✉ | Physical Review E 76:021501 (2007)

Electrostatically-tuned rate of peptide self-assembly resolved by multiple particle tracking

T Savin & PS Doyle ✉ | Soft Matter 3:1194 (2007)

Role of a finite exposure time on measuring an elastic modulus using microrheology

T Savin & PS Doyle ✉ | Physical Review E 71:041106 (2005)

Static and dynamic errors in particle tracking microrheology

T Savin & PS Doyle ✉ | Biophysical Journal 88:623 (2005)

Presentations

invited / contributed

APS Division of Fluid Dynamics 71st Annual Meeting (Atlanta GA, USA, Nov 18-20 2018)
Chemical Engineering & Biotechnology, University of Cambridge (Cambridge, UK, Nov 22 2017)
Early Detection Programme, CRUK Cambridge Cancer Centre (Cambridge, UK, Oct 30 2017)
47th Cambridge Ophthalmological Symposium, St John’s College (Cambridge, UK, Sep 7-8 2017)
Gordon Research Seminar - Soft Condensed Matter Physics (New London NH, USA, Aug 12-13 2017)
Cell and Developmental Biology, University College London (London, UK, Apr 27 2016)
IOP Advanced School in Soft Condensed Matter (Cambridge, UK, Apr 3-6 2016)
APS Annual March Meeting (Baltimore MD, USA, Mar 14-18 2016)
Research Interfaces Workshop, Cambridge Stem Cell Institute (Cambridge, UK, Oct 28 2015)
Café Synthetique, Cambridge Synthetic Biology (Cambridge, UK, Oct 19 2015)
Biological and Soft Systems, Cavendish Laboratory (Cambridge, UK, Mar 6 2015)
Jesus College Engineering Society (Cambridge, UK, Nov 7 2014)
Fluid Dynamics of Living Systems, NSF-sponsored Workshop (Arlington VA, USA, Sep 15 2014)
Department of Mechanical Engineering, MIT (Cambridge MA, USA, Feb 27 2013)
Physique & Mécanique des Milieux Hétérogènes, ESPCI (Paris, France, Feb 22 2013)
Center for Biomedical Engineering, Brown University (Providence RI, USA, Feb 5 2013)
Department of Engineering, University of Cambridge (Cambridge, UK, Jan 21 2013)
AIChE Annual Meeting (Pittsburgh PA, USA, Oct 28 - Nov 2 2012)
Department of Mechanical Engineering, Johns Hopkins University (Baltimore MD, USA, Oct 4 2012)
Department of Bioengineering, Stanford University (Palo Alto CA, USA, Aug 28 2012)
6th International Workshop on Nonequilibrium Thermodynamics (Røros, Norway, Aug 19-24 2012)
Department of Chemical Engineering, Stanford University (Palo Alto CA, USA, Jun 5 2012)
MODIFY European Consortium Meeting (Antwerp, Belgium, May 3-4 2012)
Department of Civil & Environmental Engineering, MIT (Cambridge MA, USA, Mar 2 2012)
Biophysics Seminar Series, MIT (Cambridge MA, USA, Feb 29 2012)
APS Annual March Meeting (Boston MA, USA, Feb 27 - Mar 2 2012)
MODIFY European Consortium Meeting (Zürich, Switzerland, Dec 8-9 2011)
Swiss Soft Days 6th Meeting (Zürich, Switzerland, Oct 28 2011)
Workshop on Dynamics of Interfaces, Lorentz Center (Leiden, the Netherlands, Sep 26-30 2011)
MODIFY European Consortium Meeting (Athens, Greece, Jun 9-10 2011)
Soft Matter Physics Approaches to Biology, KITP video (Santa Barbara CA, USA, May 23-27 2011)
Workshop on Mechanics and Growth of Tissues: from Development to Cancer, MPI (Dresden, Germany, Mar 21-25 2011)
Biophysical Society 55th Annual Meeting (Baltimore MD, USA, Mar 5-9 2011)
MODIFY European Consortium Meeting (Leuven, Belgium, Dec 2-3 2010)
Biologically Oriented Materials, ETH Zürich (Zürich, Switzerland, Nov 8 2010)
Swiss Soft Days 2nd Meeting (Lausanne, Switzerland, Jun 23 2010)
MODIFY European Consortium Meeting (Paris, France, Jun 10-11 2010)
Physical Systems Biology and Non-Equilibrium Soft Matter, University of Zürich (Zürich, Switzerland, Mar 25 2010)
WingX Initiative Meeting (Zürich, Switzerland, Mar 17 2010)
APS Division of Fluid Dynamics 62nd Annual Meeting (Minneapolis MN, USA, Nov 22-24 2009)
Institut für Polymere, ETH Zürich (Zürich, Switzerland, Jul 1 2009)
Biophysical Society 53rd Annual Meeting (Boston MA, USA, Feb 28 - Mar 4 2009)
Engineering and Applied Sciences, Harvard University (Cambridge MA, USA, Jun 15 2007)
Center for Soft Matter Research, NYU (New York NY, USA, May 3 2007)
The Society of Rheology 77th Annual Meeting (Vancouver BC, Canada, Oct 16-20 2005)
Dupont MIT Alliance Annual Student Symposium (Cambridge MA, USA, Sep 20 2005)
Dupont MIT Alliance Annual Research Symposium (Wilmington DE, USA, May 20 2005)
The Society of Rheology 76th Annual Meeting (Lubbock TX, USA, Feb 13-17 2005)
AIChE Annual Meeting (Austin TX, USA, Nov 7-12 2004)
Dupont MIT Alliance Annual Student Symposium (Cambridge MA, USA, Oct 13 2004)
Dupont MIT Alliance Annual Research Symposium (Wilmington DE, May 28 2004)
APS Annual March Meeting (Montreal QC, Canada, Mar 22-26 2004)
AIChE Annual Meeting (San Francisco CA, USA, Nov 16-21 2003)
The Society of Rheology 75th Annual Meeting (Pittsburgh PA, USA, Oct 12-16 2003)
Dupont MIT Alliance Annual Student Symposium (Cambridge MA, USA, Sep 22 2003)
DuPont Co.'s Marshall Laboratory (Philadelphia PA, USA, Aug 15 2003)
Séminaire Matière Molle & Biologie, LBHP (Paris, France, Jun 27 2003)
The Society of Rheology 74th Annual Meeting (Minneapolis MN, USA, Oct 13-17 2002)
Dupont MIT Alliance Annual Student Symposium (Cambridge MA, USA, Sep 23 2002)
Department of Physics & Astronomy, UPenn (Philadelphia PA, USA, Apr 18 2002)

Press

Our numerical model of fibers with integrated mechanochemical switches was the subject of an opinion article:

New & Notable article in Biophysical Journal, November 2012.

Our work on the gut looping morphogenesis was featured in several mainstream and specialized media, including:

Editorial article in médecine/sciences, December 2011.

Dispatch article in Current Biology, October 2011.

La Recherche, French language popular science magazine, October 2011.

Research Highlights articles in Nature Physics, Reviews Gastroenterology & Hepatology, Reviews Molecular Cell Biology and Materials, September 2011.

Science & Society in EMBO Reports, October 2015.

Article in Biomedical Computation Review, April 2016.

Science in Action

Science in Action on the BBC, Aug 11 2011, Jump to 9'10''.

Artwork

Please contact us if you want to use images or movies from this website.

Chemical Society ReviewsThe image depicts the structural colors arising from the helicoidal arrangements of natural fibrils in the cell wall of some plants and beetles. Such organization can be mimicked artificially using self-assembly. In this case, we used the mimicked colors of Pollia fruits as a texture. The picture was used for the back cover of the December 2016 issue of Chemical Society Reviews.

Biophysical JournalThis image shows various fibronectin repeats, arranged into parallel chains, slowly transforming to the "bead-spring" model we invented to describe such chains and their assemblies. We provided a similar design for the cover of the November 2012 issue of Biophysical Journal. More details about the image can be found on the blog of the Biophysical Society.

médecine/sciencesWe designed this composite picture to show that our approach on modeling the gut morphogenesis borrows ideas from the classical study by D'Arcy Thompson, On Growth and Form, which is often illustrated by the Nautilus shell. This image serves as the cover for the December 2011 issue of médecine/sciences.

Dupont MIT AllianceWe obtained this image of an hydrogel structure, formed from peptide self-assembly, by using a technique called "Quick-Freeze Deep-Etch" transmission electron microscopy. The colors were added, and the green dots are 100nm spherical particles. Similar images were used by Felice Frankel for creating a booklet to visually communicate our research.

Videos

Please contact us if you want to use images or movies from this website.

Science in Action

This movie shows the equilibration of a Lennard-Jones fluid simulated using molecular dynamics. The particles are initially aligned on a lattice, and finally form a drop of liquid in coexistence with its vapor. A transient bubble can be seen inside the drop. The duration of the movie is about 100 picoseconds (i.e. 0.0000000001 seconds), the length of the box about 10 nanometers (i.e. 0.00000001 meters). The simulations were performed by Marco Schweizer.